Heavier Diferrocenylpnictogenium Ions.

The synthesis, characterization and reactivity of the diferrocenylphosphenium ion [FcP] was extended to the heavier diferrocenylpnictogenium ions, [FcE] (E=As, Sb, Bi). The lighter diferrocenylnitrenium ion, [FcN], was detected by mass spectrometry, but could not be isolated. The molecular structures of [FcE] (E=P, As, Sb, Bi) reveal intramolecular coordination of the iron atoms, which counterbalance the electron deficiency of the pnictogens without affecting the strong Lewis acidities, which were determined according to the method of Gutmann and Beckett.

Electronic Coupling in Triferrocenylpnictogens.

From a fundamental perspective, studies of novel mixed-valent complexes containing ferrocenyl units are motivated by the prospect of improving and extending electron transfer models and theories. Here, the series of triferrocenylpnictogens FcE was extended to the heavier analogues (E = As, Sb, and Bi), and the influence of the bridging atom was investigated with FcP as a reference. Electrochemical studies elucidate the effect of electrostatic contribution on the large redox splitting (Δ ) exhibited by the compounds and solvent stabilization in the case of FcAs.

TSLP as a Potential Therapy in the Treatment of CRLF2 B Cell Acute Lymphoblastic Leukemia.

Cytokine receptor-like factor 2 B-cell acute lymphoblastic leukemia (CRLF2 B-ALL) is a high-risk subtype characterized by CRLF2 overexpression with poor survival rates in children and adults. CRLF2 and interleukin-7 receptor alpha (IL-7Rα) form a receptor for the cytokine thymic stromal lymphopoietin (TSLP), which induces JAK/STAT and PI3K/AKT/mTOR pathway signals. Previous studies from our group showed that low TSLP doses increased STAT5, AKT, and S6 phosphorylation and contributed to CRLF2 B-ALL cell survival.

Preclinical study analysis of massive magnesium alloy graft for calcaneal fractures.

The highly comminuted calcaneal fractures represent a challenge for surgeons and require bone grafts for a good clinical outcome. Postoperative results are generally associated with increased morbidity and long periods of inactivity. The biomedical community promotes the use of artificial materials for grafts in order to achieve improved results.

Bulky Polyfluorinated Terphenyldiphenylboranes: Water Tolerant Lewis Acids.

Protocols for the synthesis of the bulky polyfluorinated triarylboranes 2,6-(C F ) C F B(C F ) (1), 2,6-(C F ) C F B[3,5-(CF ) C H ] (2), 2,4,6-(C F ) C H B(C F ) (3), 2,4,6-(C F ) C H B[3,5-(CF ) C H ] (4) were developed. All boranes are water tolerant and according to the Gutmann-Beckett method, 1-3 display Lewis acidities larger than that of the prominent B(C F ) .