Conductive hyaluronic acid/phytanic acid hydrogel to deliver recombinant human amelogenin for diabetic wound repair.

Diabetic wounds present a considerable challenge in modern medicine due to their prolonged healing process, driven by sustained inflammation and impaired vascular regeneration. This study introduces a novel hydrogel network through osmosis, utilizing hyaluronic acid (HA) and phytic acid (PA) for their anti-inflammatory and antioxidant properties, respectively. By incorporating recombinant Human Amelogenin (rhAM), known for its angiogenic potential, we aimed to develop the HA-PA-rhAM hydrogel to enhance wound healing in diabetic rats.

Isolation of an endophytic yeast for improving the antibacterial activity of water chestnut Jiaosu: Focus on variation of microbial communities.

Recent years have seen an increase in the development of functional Jiaosu products, including eco-friendly Jiaosu and antimicrobial healthcare fermentation products. As a result, research on the antibacterial activity of Jiaosu has attracted attention. In the present study, the endophytic yeast WCF016, which exhibits antibacterial activity against Escherichia coli and Staphylococcus aureus, was isolated from the peel of water chestnut and identified as Candida sake via morphological and phylogenetic analyses based on 26S rDNA D1/D2 region sequencing.

Numerical testing method and mechanical property evaluation of large particle size asphalt mixture.

The large particle size asphalt mixture with nominal maximum aggregate size 53 mm(LSAM-50) has good technical and economic performance and will become an effective technical way to build a full-thick long-life asphalt pavement with Chinese characteristics. In order to reveal the mechanical properties and influencing factors of LSAM-50 in depth, a numerical test method for the mechanical properties of the large particle size LSAM-50 asphalt mixture was developed, and a reasonable specimen size for LSAM-50 performance test was proposed by combining the numerical test and the indoor test. The results show that: LSAM-50 numerical test conditions are the calculation time step 10-3 s/step, the loading rate is 2 mm/min (uniaxial compression numerical test) and 50 mm/min (splitting numerical test) when LSAM-50 numerical experiment calculation rate and numerical experiment accuracy are better; after the size of the specimen reaches 200×160mm, the influence of the size effect is eliminated.

Functional proteins/peptides targeting to clear Amyloid-β for Alzheimer's disease therapy.

Alzheimer's disease (AD) is a significant neurodegenerative disorder primarily affecting individuals over the age of 65. It is characterized by impairments in memory, thinking, analytical judgment, visuospatial recognition, and mood. In recent years, the development of protein and peptide drugs targeting amyloid-beta (Aβ) has gained momentum, with several therapies entering clinical trials and even receiving marketing approval.

Bioactive Products Targeting C-Met As Potential Antitumour Drugs.

Unlabelled: Mesenchymal‒epithelial transition factor (c-Met), a receptortyrosine kinase (RTK), plays a vital role in cell proliferation, migration and invasion, and tumour metastasis.

Objective: With increasing duration of treatment, many tumours gradually develop drug resistance. Therefore, novel antitumour drugs need to be developed to treat patients with tumours.