Publications by authors named "C Stefanelli"
Background: The Antarctic krill Euphausia superba is a keystone species in the Southern Ocean ecosystem. This crustacean has an ancestral clock whose main components have been identified and characterized in the past few years. However, the second feedback loop, modulating clock gene expression through two transcription factors, VRI and PDP1, has yet to be described.
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- miR-210 is a highly conserved microRNA involved in various physiological processes including responses to low oxygen and cancer, with new roles emerging in eye health; its absence in model organisms leads to significant retinal degeneration.
- Research revealed that while overexpression of miR-210 does not affect retinal health, knockout of miR-210 in mice resulted in photoreceptor degeneration, although no parallel changes in lipid metabolism were found between flies and mice.
- The study detected distinct gene expression changes in miR-210 knockout models, highlighting issues beyond the retina, such as potential neuronal deficiencies that could affect overall signal processing.
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- Camelina cake (CAM) is explored as a substitute for soybean meal in piglet diets, with various doses (4%, 8%, 12%) tested for impacts on growth and gut health.
- The study found that higher doses of CAM negatively affected growth rates and feed intake in the early weeks post-weaning, while also increasing liver weight and gut microbiome diversity.
- Overall, CAM showed potential as an alternative protein source but indicated dose-dependent challenges related to piglet growth performance.
The incidence of hepatocellular carcinoma (HCC) is increasing, and 40% of patients are diagnosed at advanced stages. Over the past 5 years, the number of clinically available treatments has dramatically increased for HCC, making patient management particularly complex. Immune checkpoint inhibitors (ICIs) have improved the overall survival of patients, showing a durable treatment benefit over time and a different response pattern with respect to tyrosine kinase inhibitors (TKIs).
View Article and Find Full Text PDFBackground: Metabolic reprogramming is a well-known marker of cancer, and it represents an early event during hepatocellular carcinoma (HCC) development. The recent approval of several molecular targeted agents has revolutionized the management of advanced HCC patients. Nevertheless, the lack of circulating biomarkers still affects patient stratification to tailored treatments.
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