Publications by authors named "C Steenholdt"
Stem cell research is currently undergoing a promising transformation from primarily basic research to increasing emphasis on translation and clinical trials. To reach patients, however, stem cell treatments need to be not only technically but also economically viable. In this commentry we present insights into emerging pricing models that may help ensure access to advanced and expensive treatments like stem cell therapies.
View Article and Find Full Text PDFBackground: In settings where general anaesthesia is unnecessary, effective sedation, analgesia and local anaesthesia are crucial for optimal outcomes. Traditionally, sedation have been managed and controlled by healthcare professionals, but advancements in pharmacology and technology have renewed the way we are able to sedate. Patient-controlled sedation (PCS) offers a promising approach, allowing patients to adjust their sedation levels during procedures.
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- The study aimed to compare how quickly different advanced therapies can induce remission in patients with Crohn's disease through a network meta-analysis of randomized controlled trials.
- Results showed that infliximab (with azathioprine or alone) led to the highest early remission rates within 6 weeks, outperforming several other therapies, while adalimumab and risankizumab showed non-significant superiority.
- For patients who had previously been treated with other biologics, upadacitinib and risankizumab provided the best clinical responses, although infliximab wasn't assessed in this specific group.
Article Synopsis
- A study was conducted to evaluate how prednisolone affects clinical outcomes and safety in ulcerative colitis patients treated with infliximab, with a focus on corticosteroid-free clinical remission (CFCR).
- Among the 147 patients reviewed, there was no overall association between prednisolone use and CFCR at weeks 14 or 52, but standard tapering of prednisolone showed better results compared to faster tapering regimens.
- Despite no impact on infliximab levels, higher infection rates were noted in patients taking prednisolone, especially in those with greater disease severity, suggesting that corticosteroid therapy may benefit certain patients.