Disposable pipette extraction for the simultaneous determination of biperiden and three antipsychotic drugs in human urine by GC-nitrogen phosphorus detection.

Background: Disposable pipette extraction with reversed-phase sorbent is proposed for the fast and simple GC determination of the antipsychotic drugs chlorpromazine, olanzapine, clozapine and biperiden - an anticholinergic drug - in human urine. The method was validated and successfully applied to postmortem urine samples. The analytical run was 11 min and lidocaine was used as the internal standard.

Mitral valvotomy in a patient with dextroversion and skeletal chest deformities.

A case of acquired mitral stenosis in a 29-year-old male with cardiac dextroversion and bone abnormalities of the chest is described. Open mitral valvotomy through a median sternotomy was planned but could not be executed and a closed valvotomy was easily performed.