Navigating ambivalence: A qualitative study of young fitness self-trackers' engagement with body ideals through social media.

This article explores how social media are involved in imagining and sensing body ideals among young fitness self-trackers in Denmark (age 15-24). The analysis is based on 20 interviews and contributes to existing research on social media, body image and self-tracking by showing that social media are central for the fitness practices of the participants, but also that gaining access to practical knowledge, motivational material and visual goals seem to be more important motivations for social media use than personal sharing and interaction. Social media are furthermore understood by the participants as unavoidable, but ambivalent terrains in the sense that cognitive and affective benefits, like knowledge or motivation, can only be accessed and felt by handling the risk of also encountering misinformation and demotivating images of idealised or deceptive bodies.

The impact of human CES1 genetic variation on enzyme activity assessed by ritalinic acid/methylphenidate ratios.

The present clinical trial investigated the impact of selected SNPs in CES1 on the metabolic activity of the enzyme. For this purpose, we used methylphenidate (MPH) as a pharmacological probe and the d-RA/d-MPH (metabolite/parent drug) ratios as a measure of enzymatic activity. This metabolic ratio (MR) was validated against the AUC ratios (AUC /AUC ).

Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate.

Carboxylesterase 1 (CES1) metabolizes methylphenidate and other drugs. CES1 gene variation only partially explains pharmacokinetic (PK) variability. Biomarkers predicting the PKs of drugs metabolized by CES1 are needed.

Reappraisal of the genetic diversity and pharmacogenetic assessment of CES1.

The CES1 gene encodes a hydrolase that metabolizes important drugs. Variants generated by exchange of segments with CES1P1 complicate genotyping of CES1. Using a highly specific procedure we examined DNA samples from 200 Caucasians and identified 46 single nucleotide variants (SNVs) in CES1 and 21 SNVs in CES1A2, a hybrid composed of CES1 and CES1P1.

The Pharmacokinetics of Enalapril in Relation to CES1 Genotype in Healthy Danish Volunteers.

This study investigated the influence of variations in the carboxylesterase 1 gene (CES1) on the pharmacokinetics of enalapril. Forty-three healthy, Danish, Caucasian volunteers representing different pre-defined genotypes each received 10 mg of enalapril. At specified time-points, plasma concentrations of enalapril and the active metabolite enalaprilat were measured.