Publications by authors named "C Sprissler"
Metacaspases (MCAs) are cysteine peptidases expressed in plants, fungi and protozoa, with a caspase-like histidine-cysteine catalytic dyad, but differing from caspases, for example, in their substrate specificity. The role of MCAs is subject to debate: roles in cell cycle control, in cell death or even in cell survival have been suggested. In this study, using a Leishmania major MCA-deficient strain, we showed that L.
View Article and Find Full Text PDFThe spleen tyrosine kinase (SYK) was identified as an oncogenic driver in a broad spectrum of hematologic malignancies. The in vivo comparison of three SYK containing oncogenes, SYK(wt), TEL-SYK and IL-2-inducible T-cell kinase (ITK)-SYK revealed a general myeloexpansion and the establishment of three different hematologic (pre)diseases. SYK(wt) enhanced the myeloid and T-cell compartment, without leukemia/lymphoma development.
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- * Mice with T cell-specific ITK-Syk expression develop aggressive T cell lymphoproliferation and B cell expansion much earlier than previously observed in other models.
- * The early aggressive phenotype is linked to low levels of Blimp-1 induction due to ITK-Syk expression, while high levels promote T cell differentiation that prevents malignancy, suggesting a delicate balance in oncogene expression is crucial for cancer development.
Article Synopsis
- Peripheral T-cell lymphomas (PTCL) are hard to treat and can be deadly because regular chemotherapy doesn't work well on them.
- Scientists found a mutation called ITK-SYK in a lot of PTCL cases and discovered it causes T-cell diseases in mice, with symptoms popping up just weeks after infection.
- They showed that blocking the SYK protein's activity can stop the disease, suggesting that targeting this mutation could be a good treatment option for people with similar cancer types.
In lysine biosynthesis, dihydrodipicolinate reductase (DHDPR) catalyses the formation of tetrahydrodipicolinate. Unlike DHDPR enzymes from Escherichia coli and Mycobacterium tuberculosis, which have dual specificity for both NADH and NADPH as co-factors, the enzyme from Thermotoga maritima has a significantly greater affinity for NADPH. Despite low sequence identity with the E.
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