Publications by authors named "C Sprenger"
Article Synopsis
- * A 41-year-old Turkish woman experienced pruritus and tenderness in her chest, having previously been treated for recurrent abscesses and diagnosed with HES involving multiple organs.
- * Biopsy results indicated eosinophilic infiltration in her rash, and her ongoing respiratory symptoms and childhood asthma hinted at EGPA, highlighting the importance of recognizing these conditions during Wells syndrome investigation.
Article Synopsis
- Metastatic castration-resistant prostate cancer is still incurable, despite recent treatments, and tumors show increased glycolysis as they progress.
- The study introduces BKIDC-1553, a new small-molecule compound that inhibits glycolysis specifically in prostate cancer cells without causing severe toxicity, and demonstrates promising results in preclinical models.
- BKIDC-1553 shows effective growth inhibition in various prostate cancer models and has safety and pharmacokinetic properties that suggest it’s ready for clinical trials to treat advanced prostate cancer.
Article Synopsis
- The study focuses on the treatment and outcomes of popliteal artery aneurysms (PAAs) in women, who make up only 5% of PAA patients, highlighting the lack of extensive evidence in this area.
- Data was collected from the POPART Registry, a large European registry involving 42 centers, examining clinical presentation and surgical outcomes since 2010.
- Findings revealed that female patients had smaller aneurysms and higher rates of symptoms before surgery, along with increased complications like impaired wound healing and the need for additional procedures post-surgery compared to men.
Nature employs spontaneous self-organization of supramolecular bonds to create complex matter capable of adaptation and self-healing. Accordingly, the self-sorting of unlike ligands towards a cooperative heteroleptic complex or narcistic homoleptic association in a mixed ligand system is frequently employed to form interchangeable stimuli-responsive complex geometries with a wide range of applications. This notion is however just rarely employed in the organization of polymer networks.
View Article and Find Full Text PDFThe Androgen Receptor (AR) is a ligand (androgen) activated transcription factor and a member of the nuclear receptor (NR) superfamily. It is required for male sex hormone function. AR-FL (full-length) has the domain structure of NRs, an N-terminal domain (NTD) required for transactivation, a DNA-binding domain (DBD), a nuclear localization signal (NLS) and a ligand-binding domain (LBD).
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