Publications by authors named "C Spino"
Background: Cardiovascular autonomic neuropathy (CAN) and inflammation predict more severe outcomes in type 1 diabetes (T1D). However, the link between CAN and inflammation in T1D remains unclear. We examined associations between CAN measures and inflammatory biomarkers in individuals with T1D.
View Article and Find Full Text PDFImpact of the CAPTURE COPD Screening Tool in US Primary Care: A Cluster Randomized Trial.
Am J Respir Crit Care Med
December 2024
The impact of COPD screening on US primary care clinician behavior and patient outcomes is unclear. Assess the impact of receiving CAPTURE (COPD Assessment in Primary Care to Identify Undiagnosed Respiratory Disease and Exacerbation Risk) screening scores on clinical and patient outcomes. Cluster randomized trial included 49 usual care (COPD education only) and 51 intervention (COPD and CAPTURE education plus screening scores) primary care practices.
View Article and Find Full Text PDFIntroduction: There are two main schools of thought about statistical inference: frequentist and Bayesian. The frequentist approach relies solely on available data for predictions, while the Bayesian approach incorporates both data and prior knowledge about the event of interest. Bayesian methods were developed hundreds of years ago; however, they were rarely used due to computational challenges and conflicts between the two schools of thought.
View Article and Find Full Text PDFStent Omission after Ureteroscopy and Lithotripsy (SOUL) in the Michigan Urological Surgery Improvement Collaborative (MUSIC): study protocol for a pragmatic prospective combined randomized and observational clinical trial.
Trials
December 2024
Article Synopsis
- - Ureteral stents are commonly used after ureteroscopy to prevent complications from kidney stones, yet they can cause significant pain and urinary issues, which has led to calls for their omission in many cases.
- - Guidelines support not using stents in uncomplicated surgeries, but over 80% of procedures still involve them, partly due to insufficient evidence about their impact on pain and patient outcomes.
- - A new study is being conducted where patients randomly choose whether to have a stent or not, while those who refuse randomization will be observed based on the doctor's decision, aiming to gather real-world data on the effectiveness of stent omission.
Introduction: Fluid overload is a source of substantial morbidity for adults and children with nephrotic syndrome (NS). Preparation and Rationale for a Fluid Overload in Nephrotic Syndrome Clinical Outcomes Assessment Set for Drug Development (Prepare-NS, 5UG3FD007308) was funded by the US Food and Drug Administration to develop a core set of patient-reported and observer-reported (for young children) outcome measures of fluid overload for use in pharmaceutical trials across the lifespan.
Methods: The Prepare-NS study team developed the proposed context of use with input from stakeholders.