Publications by authors named "C Sparano"
Group 1 innate lymphoid cells (ILCs) encompass NK cells and ILC1s, which have non-redundant roles in host protection against pathogens and cancer. Despite their circulating nature, NK cells can establish residency in selected tissues during ontogeny, forming a distinct functional subset. The mechanisms that initiate, maintain, and regulate the conversion of NK cells into tissue-resident NK (trNK) cells are currently not well understood.
View Article and Find Full Text PDFArticle Synopsis
- The hypothalamus-pituitary testis axis and growth hormone (GH) pathways are interconnected, but GH's impact on male sexual function and fertility remains debated due to mixed research findings.
- GH excess contributes to male sexual health issues, notably causing erectile dysfunction in about 40.2% of cases and impairing fertility by reducing sperm quality, including concentration and motility.
- GH deficiency may also lead to erectile dysfunction, though its effects on fertility are not well established; overall, GH disorders adversely affect male sexual and general health, with insufficient research on testosterone replacement therapy benefits.
Introduction: Erectile dysfunction (ED) is a neglected complication in patients with pre-diabetes or diabetes mellitus (DM).
Areas Covered: A summary and review of the role of standard ED treatment and the contribution of lifestyle modification and hypoglycemic drugs.
Expert Opinion: Oral phosphodiesterase type 5 inhibitors (PDE5i) represent the first-line therapy even in patients with DM.
Purpose: Although anti-hypertensive medications, including thiazides and β-blockers (BBs) in particular, have been suggested to cause erectile dysfunction (ED) their real contribution is still conflicting. The aim of this paper is to summarize available evidence providing an evidence-based critical analysis of the topic.
Methods: An overall comprehensive narrative review was performed using Medline, Embase and Cochrane search.
Article Synopsis
- Numerous studies indicate that men often engage in sexual relationships with younger women, with age differences linked to sexual dysfunctions in men due to aging-related health issues.
- The study, involving 4,055 men at an andrology unit, explores how the age gap between partners affects male sexual health and relationship dynamics.
- Results indicate that men pursuing younger partners tend to exhibit certain personality traits and hormonal levels but don’t experience improved sexual performance, and an age gap correlates with higher rates of future cardiovascular events in older men.*