Publications by authors named "C Spadavecchia"
Introduction: Use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is still in the focus of research, in which pigs are commonly involved. During VA-ECMO, cardiovascular parameters are artificially manipulated and therefore not reliable indicators of nociception. Nociceptive withdrawal reflex (NWR) thresholds can be a suitable alternative in such a context.
View Article and Find Full Text PDFStudy objective was to evaluate whether the application of a lip twitch could be proposed as conditioning stimulus in the context of a novel Conditioned Pain Modulation (CPM) assessment paradigm for use in horses. The study was a prospective, experimental, randomized trial. Twelve healthy horses were evaluated in two experimental sessions.
View Article and Find Full Text PDFArticle Synopsis
- Minipigs are commonly used in biomedical research, but there is limited information on how experimental procedures affect their pain perception, prompting the need for non-invasive pain assessment methods.
- The study aimed to establish mechanical and thermal pain thresholds in healthy Göttingen Minipigs and assess their reliability before and after applying painful and sham conditioning stimuli.
- Results indicated that mechanical thresholds were generally more reliable than thermal thresholds, with a notable pro-nociceptive response observed, suggesting that future pain assessments in this species should focus on mechanical testing.
Inhalational anaesthetic agents are routinely used in veterinary anaesthesia practices, yet their consumption contributes significantly to greenhouse gas emissions and environmental impact. We conducted a 55-day observational study at a veterinary teaching hospital in Switzerland, monitoring isoflurane and sevoflurane consumption across small, equine and farm animal clinics and analysed the resulting environmental impact. Results revealed that in total, 9.
View Article and Find Full Text PDF