Publications by authors named "C Soret"
Objectives: The current study aimed to explore attitudes toward genetic germline testing and intentions to test in Latinas from Southern California. We hypothesized that patients' acculturation and education levels, as well as comfort with health care providers, are positively associated with attitudes and intentions toward genetic testing.
Methods: A survey was offered concurrently to Latinx female patients at a gynecologic oncology practice and to unaffiliated Latinx community members.
Simple and standardized approaches for genome analysis of human papillomavirus (HPV) by next-generation sequencing are needed. The aim of the study was to develop a protocol for direct deep sequencing of high-risk (hr) HPV strains, based on the widely used commercial Hybrid Capture 2 (QIAGEN) test, without any additional probe design. This protocol was applied to 15 HPV-positive and two HPV-negative cervical samples or cell lines and validated at the genotype level by comparing the sequencing results to those obtained using a commercial genotyping kit.
View Article and Find Full Text PDFArticle Synopsis
- HPV is a significant risk factor for head and neck squamous cell carcinoma (HNSCC), which is on the rise globally, especially in younger patients under 45 years of age.
- A study at Besançon University Hospital analyzed HPV DNA and p16 expression in HNSCC patients, including a group under 45 and one aged 45 and older.
- Results showed that HPV infection prevalence was around 11.7%, and although HPV16 was the main strain identified, p16 expression levels were similar across both age groups, indicating potential for p16 as a general prognostic biomarker for HNSCC.
Article Synopsis
- The study looks at a patient and their relatives who have unusual skin growths caused by human papilloma virus (HPV).
- The patients have a specific genetic change that makes a part of their immune cells (T cells) not work properly, which affects how their body fights off HPV.
- Even though their T cells don’t respond well to HPV, the patients can still make antibodies against the viruses, showing that they can fight infections differently than expected.
Article Synopsis
- Scientists believe that vaccines and health screenings can help completely get rid of cervical cancer!
- Keeping track of HPV infections is really important to see how well these vaccines and screenings are working!
- New research shows that cervical samples can be safely stored on special cards for more than 4 years, allowing scientists to test them again later!