Publications by authors named "C Sobin"

Current child blood lead (Pb) screening guidelines assume that blood lead levels (BLLs) are relatively stable over time, and that only youngest children are vulnerable to the damaging effects of lower-range BLLs. This study aimed to test the stability of lower-range (≤ 10 μg/dL) child BLLs over time, and whether lower-range BLLs diminished with age among children aged 6 months to 16 years living in a lower-income neighborhood with a density of pre-1986 housing and legacy contamination. Age, sex, family income, age of residence, and/or residence proximity to point sources of Pb, were tested as potential additional factors.

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Established methods for using standardized dust wipes to collect and measure total lead in household dust are readily available but the use of dust wipes to measure bioaccessible lead (BaPb) is less clear. This study compared two in vitro methods for estimating the proportion of BaPb in dust collected into dust wipes including the US-EPA's bioaccessible assay (IVBA) method at two pH (1.5 and 2.

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Policy Points Child lead poisoning is associated with socioeconomic inequity and perpetuates health inequality. Methods for testing and detection of child lead poisoning are ill suited to the current demographics and characteristics of the problem. A three-pronged revision of current testing approaches is suggested.

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Unlabelled: Child lead poisoning damages central nervous system, immune, and renal function, and is the longest-standing public health epidemic in U.S. history.

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Article Synopsis
  • There is a significant challenge in integrating mechanistic data into human health assessments because these studies are more numerous and diverse than traditional health endpoint studies.
  • A structured decision-making process is proposed to better organize and weigh this mechanistic data, potentially improving the consistency and efficiency of health risk assessments.
  • At a symposium by the Developmental Neurotoxicology Society in 2016, experts discussed how factors like exposure context and behavioral changes could help interpret neurotoxicology data, and acknowledged ongoing research to refine evaluation frameworks.
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