Publications by authors named "C Smirne"
Article Synopsis
- Direct-acting antivirals (DAAs) have made hepatitis C treatment much easier, but there’s limited info on how they work for patients with glucose-6-phosphate dehydrogenase deficiency (G6PDd).
- A study looked at 2754 HCV-positive patients from 2015 to 2023, focusing on 38 with confirmed G6PDd, while monitoring their health closely during and after treatment.
- Results showed no significant health issues or adverse events related to the treatment, with effectiveness similar to those without G6PDd, indicating that DAAs are safe for HCV treatment in these patients.
Previous studies reported that the hepatitis C virus (HCV) could help disseminate the hepatitis D virus (HDV) in vivo through hepatitis B virus (HBV)-unrelated ways, but with essentially inconclusive results. To try to shed light on this still-debated topic, 146 anti-HCV-positive subjects (of whom 91 HCV/HIV co-infected, and 43 with prior HCV eradication) were screened for anti-HDV antibodies (anti-HD), after careful selection for negativity to any serologic or virologic marker of current or past HBV infection. One single HCV/HIV co-infected patient (0.
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- Diagnosis of AOSD is complex and often requires ruling out other conditions, making it a lengthy process.
- The treatment for MAS involves high-dose corticosteroids and may include additional medications, with a multidisciplinary team of specialists crucial for effective management, as illustrated by a case of a young woman who successfully recovered using a specific treatment protocol.
Article Synopsis
- MEN1 is a genetic condition that can cause tumors in different glands, and scientists are trying to understand more about it by studying families affected by this disease.
- A 35-year-old woman with MEN1 and her kids were tested for changes in the MEN1 gene, which can lead to serious health issues.
- They discovered a new change in the MEN1 gene that might be linked to the woman's condition, suggesting that more careful genetic testing is important for people with MEN1.
Role of the co-stimulatory molecule inducible T-cell co-stimulator ligand (ICOSL) in the progression of experimental metabolic dysfunction-associated steatohepatitis.
Front Immunol
December 2023
Background And Aims: Inducible T-cell Co-Stimulator (ICOS) present on T-lymphocytes and its ligand ICOSL expressed by myeloid cells play multiple roles in regulating T-cell functions. However, recent evidence indicates that reverse signalling involving ICOSL is also important in directing the differentiation of monocyte-derived cells. In this study, we investigated the involvement of ICOS/ICOSL dyad in modulating macrophage functions during the evolution of metabolic dysfunction-associated steatohepatitis (MASH).
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