Publications by authors named "C Skevaki"
Long COVID: Pathophysiology, current concepts, and future directions.
J Allergy Clin Immunol
December 2024
Long COVID, an umbrella term referring to a variety of symptoms and clinical presentations that emerges in a subset of patients after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, has a significant effect on quality of life and places a substantial burden on health care systems worldwide, straining financial and human resources. The pathophysiology of long COVID remains incompletely understood, though several hypotheses have been proposed to explain different aspects of this complex condition. SARS-CoV-2 persistence, direct organ damage, innate and adaptive immune system perturbation, autoimmunity, latent virus reactivation, endothelial dysfunction, and microbiome disturbances are among the most relevant avenues for elucidating the evolution, complexity, and mechanisms of long COVID.
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- Thromboembolic complications in severe COVID-19 are linked to neutrophil-extracellular-trap (NET)-driven immunothrombosis, indicating a significant immune response issue.
- This study analyzes plasma IgA glycosylation during severe SARS-CoV-2 and Influenza A infections, finding changes in glycan structures associated with acute respiratory distress syndrome (ARDS).
- The differences in IgA glycosylation patterns between COVID-19 and Influenza A suggest that these changes could influence immune responses and NET formation, highlighting the need for further exploration of IgA's role in infectious diseases.
Background: Synthetic glucocorticoids are among the most commonly administered drugs due to their potent immunomodulatory properties. However, they may put patients at risk for infections. Their effect on the incidence of respiratory viral infections (RVIs) remains unclear.
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