Plasma metabolomic and lipidomic profiles accurately classify mothers of children with congenital heart disease: an observational study.

Introduction: Congenital heart disease (CHD) is the most common congenital anomaly, representing a significant global disease burden. Limitations exist in our understanding of aetiology, diagnostic methodology and screening, with metabolomics offering promise in addressing these.

Objective: To evaluate maternal metabolomics and lipidomics in prediction and risk factor identification for childhood CHD.

Latest Advances in Regional Anaesthesia.

Training and expertise in regional anaesthesia have increased significantly in tandem with increased interest over the past two decades. This review outlines the most recent advances in regional anaesthesia and focuses on novel areas of interest including fascial plane blocks. Pharmacological advances in the form of the prolongation of drug duration with liposomal bupivacaine are considered.