Electrochemically grafted gallic acid-chitosan: a metal-free redox platform for regiospecific oligopeptide-viral spike protein interaction.

Electrochemical grafting of gallic acid with chitosan (EgGC) voltammetrically deposited on a multitude of substrates exhibiting reversible oxidoreduction suitable for sensor construction is reported. A bioreceptor customized from the fragment antigen binding region of SARS-CoV-2 neutralizing antibodies immobilized on an EgGC matrix supported the selective/specific electrochemical signal transduction with respect to different viral loads (femtogram level) of SARS-CoV-2.

A novel interaction between RNA mA methyltransferase METTL3 and RREB1.

Regulation of gene expression is achieved through the modulation of regulatory inputs both pre- and post-transcriptionally. Methyltransferase-like 3 (METTL3) is a key player in pre-mRNA processing, actively catalyzing N6-methyladenosine (m6A). Among the most enriched mRNA targets of METTL3 is the Ras Responsive Element Binding Protein 1 (RREB1), a transcription factor which functions to govern cell fate, proliferation and DNA repair.

Highly Efficient Room Temperature NO Sensor Using Two-Phase TiO Heterogeneous Nanoparticles.

In this study, we successfully synthesized two-phase titanium oxide (TiO) heterogeneous nanoparticles (NPs) using an advanced sol-gel method, a significant stride in developing efficient, room temperature (RT) NO gas sensors. The prepared two-phase TiO heterogeneous NPs exhibited exceptional sensitivity to low concentrations of NO gas at RT. The heightened gas response was attributed to a significant presence of oxygen vacancies, creating intermediate states within the two-phase heterostructures and thus narrowing the band gap.

Profile of COVID-19 breakthrough cases and its comparison with unvaccinated COVID-19 cases among healthcare workers in a tertiary care centre in North Kerala.

Background: Healthcare workers (HCWs) were the most vulnerable group during COVID-19 pandemic and had faced many challenges including high rate of breakthrough infections.

Aims: To study the incidence of reported breakthrough infections among HCWs in Government Medical College, Kozhikode and to compare profile of COVID-19 infection between fully vaccinated and unvaccinated COVID-19 positive HCWs.

Settings And Design: The research was conducted as a prospective study for a duration of 78 weeks from 1 of March 2020 through 31 of August 2021 in Government Medical College, Kozhikode.

Investigation of TiO nanoparticle interactions in the fibroblast NIH-3T3 cells via liquid-mode atomic force microscope.

Long before we recognized how significant they were, nanoparticles were already all around in the environment. Since then, an extensive number of synthetic nanoparticles have been engineered to improve our quality of life through rigorous scientific research on their uses in practically every industry, including semiconductor devices, food, medicine, and agriculture. The extensive usage of nanoparticles in commodities that come into proximity with human skin and internal organs through medicine has raised significant concerns over the years.