Effect of Probiotic Toothpaste on Enamel Mineralization and Levels in Cleft Orthodontic Patients-A Randomized Clinical Trial.

Objective: To assess the effectiveness of probiotic and fluoride toothpaste on enamel mineralization and levels in cleft lip and/or palate patients undergoing fixed orthodontic appliance therapy.

Design: A randomized comparative trial with a 1:1 allocation ratio.

Participants: Thirty-two patients with cleft lip and/or palate undergoing fixed orthodontic appliances were recruited.

The Elements of Style for Interruptive Electronic Health Record Alerts.

Background: The proliferation of electronic health record (EHR) alerts has led to widespread alert fatigue and clinician burnout, undermining the effectiveness of clinical decision support and compromising patient safety.

Objective: We introduce a comprehensive style guide for designing interruptive alerts (IAs) in EHR systems to improve clinician engagement and reduce alert fatigue that has been approved by our institutional alert governance committees. This style guide addresses critical aspects of IAs, including format, typography, color-coding, title brevity, patient identification, and introductory text.

Causal contextual bandits with one-shot data integration.

We study a contextual bandit setting where the agent has access to causal side information, in addition to the ability to perform multiple targeted experiments corresponding to potentially different context-action pairs-simultaneously in one-shot within a budget. This new formalism provides a natural model for several real-world scenarios where parallel targeted experiments can be conducted and where some domain knowledge of causal relationships is available. We propose a new algorithm that utilizes a novel entropy-like measure that we introduce.

Novel repurposing of sulfasalazine for the treatment of adrenocortical carcinomas, probably through the SLC7A11/xCT-hsa-miR-92a-3p-OIP5-AS1 network pathway.

Background: Recent multigenomic analysis of adrenocortical carcinomas (ACCs) identified SLC7A11/xCT as a novel biomarker. The Food and Drug Administration-approved anti-inflammatory drug, sulfasalazine (SAS), induces ferroptosis by blocking SLC7A11 expression. We hypothesize that SAS could be repurposed to target ACC cells.

The Investigation of Hsp90C-Terminal Inhibitors Containing Amide Bioisosteres.

Heat Shock Protein 90 (Hsp90) is responsible for the proper folding and maturation of ~400 client protein substrates, many of which are directly associated with the ten hallmarks of cancer. Hsp90 is a great target for cancer therapy including melanoma, since Hsp90 inhibition can disrupt multiple oncogenic pathways simultaneously. In this study, we report the synthesis and anti-proliferative activity manifested by a series of Hsp90 C-terminal inhibitors against mutant BRAF and wild-type BRAF melanoma cells.