Publications by authors named "C Siri"
Article Synopsis
- Identifying cognitive impairment in Parkinson's disease is complicated due to varied symptoms and incomplete criteria for diagnosis, with existing screening tools (MMSE and MoCA) lacking a unified approach.
- The study analyzed data from 1,780 Parkinson's patients to establish effective cutoffs for MMSE and MoCA scores across different cognitive stages (normal, mild impairment, dementia).
- A new decision tree model was created, suggesting specific MMSE and MoCA scores to accurately diagnose dementia and mild cognitive impairment, improving diagnostic precision and efficiency for clinicians.
In this paper, we quantify weak protein-protein interactions in solution using cross-interaction chromatography (CIC) and surface plasmon resonance (SPR) and demonstrate that they can be modulated by the addition of millimolar concentrations of free amino acids. With CIC, we determined the second osmotic virial cross-interaction coefficient () as a proxy for the interaction strength between two different proteins. We perform SPR experiments to establish the binding affinity between the same proteins.
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- The study investigates the long-term effects of rehabilitation on Parkinson's disease patients years after undergoing Deep Brain Stimulation (DBS).
- It analyzed data from 47 patients (22 with DBS and 25 without) participating in a four-week rehabilitation program that included various exercises.
- Results showed that patients with DBS had significant improvements across multiple measures of mobility and function, highlighting the positive impact of rehabilitation, but no significant differences were found between the two groups.
A key distinguishing factor between mild cognitive impairment (MCI) and dementia in Parkinson's disease (PD) lies in the notable decrease in functioning due to cognitive impairment. The Parkinson's Disease-Cognitive Functional Rating Scale (PD-CRFS) was developed to assess functional limitations caused by cognitive impairment, while reducing the influence of motor impairment. The aim of this multicenter study was to (i) validate the Italian version of the PD-CFRS in PD, (ii) determine optimal cut-off scores for detecting MCI and dementia in PD, (iii) compare its performances with the most established functional assessment tool (IADL).
View Article and Find Full Text PDFIntroduction: Previous studies have suggested an association between Impulsive Compulsive Behaviour (ICB) and dyskinesia in Parkinson's disease (PD). However, none of these studies have employed an objective home-based measure of dyskinesia.
Objectives: To evaluate in advanced PD the relationship between ICB and dyskinesia, objectively measured with a wearable device.