Publications by authors named "C Simoneau"
Objectives: The efficacy of interventions targeting lifestyle habits, particularly dietary habits, among postpartum women is well established. However, whether these results can be translated into tangible changes in the care and services provided to this population remains unclear. Therefore, the aim is to examine the implementation outcomes of postpartum nutritional interventions delivered in healthcare, community, or eHealth settings.
View Article and Find Full Text PDFArticle Synopsis
- SARS-CoV-2 primarily targets myeloid populations, particularly human alveolar macrophages, in the lungs, where ACE2 expression allows viral entry and infection.
- The infection of these macrophages results in the production of more viruses while evading strong interferon responses, making it harder for the immune system to detect and combat the virus.
- This hidden viral reservoir in lung myeloid cells during the early stages of infection facilitates viral growth and may contribute to immune-related complications.
As SARS-CoV-2 continues to spread worldwide, tractable primary airway cell models that recapitulate the cell-intrinsic response to arising viral variants are needed. Here we describe an adult stem cell-derived human airway organoid model overexpressing the ACE2 receptor (ACE2-OE) that supports robust viral replication while maintaining 3D architecture and cellular diversity of the airway epithelium. ACE2-OE organoids were infected with SARS-CoV-2 variants and subjected to single-cell RNA-sequencing.
View Article and Find Full Text PDFThe hepatitis C virus (HCV) causes liver disease, affecting millions. Even though we have effective antivirals that cure HCV, they cannot stop terminal liver disease. We used an adult stem cell-derived liver organoid system to understand how HCV infection leads to the progression of terminal liver disease.
View Article and Find Full Text PDFArticle Synopsis
- The study explored how the airway epithelium responds to SARS-CoV-2 and its variants, using airway organoids from 20 different subjects to better understand infection mechanisms.* -
- Tetraspanin-8 (TSPAN8) was identified as a key factor that enhances SARS-CoV-2 infection, working independently of the ACE2-Spike protein interaction.* -
- Although Delta and Omicron variants showed lower infection rates than the original virus, they still altered the epithelial response, indicating potential new targets for COVID-19 treatments with TSPAN8-blocking antibodies.*