Publications by authors named "C Simon Castellvi"
Neural activity is an important biomarker for the presence of neurodegenerative diseases, cerebrovascular alterations, and brain trauma; furthermore, it is a surrogate marker for treatment effects. These pathologies may occur and evolve in a long time-period, thus, noninvasive, transcutaneous techniques are necessary to allow a longitudinal follow-up. In the present work, we have customized noninvasive, transcutaneous, diffuse correlation spectroscopy (DCS) to localize changes in cerebral blood flow (CBF) induced by neural activity.
View Article and Find Full Text PDFHyperglycemia at stroke onset is associated with poor long-term clinical outcome in numerous studies. Hyperglycemia induces intracellular acidosis, lipid peroxidation, and peroxynitrite production resulting in the generation of oxidative and nitrosative stress in the ischemic tissue. Here, we studied the effects of acute hyperglycemia on in vivo intercellular adhesion molecule-1 (ICAM-1) expression, neutrophil recruitment, and brain damage after ischemia/reperfusion in mice and tested whether the natural antioxidant uric acid was protective.
View Article and Find Full Text PDFArticle Synopsis
- Laser speckle contrast imaging (LSCI) is a powerful method for analyzing cerebral blood flow (CBF).
- The multi-exposure laser speckle imaging (MESI) technique uses rapid data capture to simulate multiple exposures in one shot, enhancing accuracy and sensitivity.
- A comparison of in vivo results showed that MESI outperforms traditional methods when applied to mouse brains under the same conditions.