Publications by authors named "C Sillaber"
During progression of myeloid neoplasms, the basophil compartment may expand substantially and in some of these patients, a basophilic leukemia is diagnosed. In patients with Ph-chromosome+ chronic myeloid leukemia, acceleration of disease is typically accompanied by marked basophilia. In other myeloid neoplasms, secondary leukemic expansion of basophils is rarely seen.
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- Personalized medicine seeks to match specific cancer treatments to individual patients based on their tumor characteristics, but current methods only assist less than 10% of patients.
- A new approach, called single-cell functional precision medicine (scFPM), was tested on 143 patients with aggressive hematologic cancers, where 39% received treatments guided by scFPM results.
- Results showed that 54% of patients treated according to scFPM experienced improved progression-free survival, with some achieving exceptional responses lasting three times longer than typical, indicating the method's clinical feasibility and effectiveness.