Publications by authors named "C Signoretto"
Article Synopsis
- Novel antimicrobial drugs, like cefiderocol, have been developed to tackle the rise of antimicrobial resistance, specifically against multidrug-resistant (MDR) Gram-negative bacilli (GNB).
- Cefiderocol, a unique siderophore cephalosporin, efficiently penetrates bacterial outer membranes, making it effective against various resistance strategies and offering a broad spectrum of action.
- Despite its effectiveness, recently identified cefiderocol-resistant strains highlight the need for new strategies in clinical practice to maintain its antibacterial efficacy.
Article Synopsis
- Shotgun metagenomics sequencing is increasingly used for studying microbial communities, but guidelines on the necessary number of sequences for accurate results are still lacking.* -
- In an experiment involving oral microbiota, it was found that using fewer than 40 million sequences leads to significant loss of information about microbial species and their quantities, while abundance estimates remained relatively stable.* -
- The study revealed that a significant portion of antimicrobial resistance genes (ARGs) were inconsistently identified or lost when fewer than 20 million sequences were used, emphasizing the need for careful planning in metagenomic experiments.*
Infections caused by are particularly difficult to treat due to the high rate of antibiotic resistance. also forms biofilms that reduce the effects of antibiotics and disinfectants. Therefore, new therapeutic approaches are increasingly required.
View Article and Find Full Text PDFspp. lung infection in cystic fibrosis has been associated with inflammation, increased frequency of exacerbations, and decline of respiratory function. We aimed to evaluate in vivo the inflammatory effects of clinical isolates exhibiting different pathogenic characteristics.
View Article and Find Full Text PDFBackground: (MG) is one of the most warning emerging sexually transmitted pathogens also due to its ability in developing resistance to antibiotics. MG causes different conditions ranging from asymptomatic infections to acute mucous inflammation. Resistance-guided therapy has demonstrated the best cure rates and macrolide resistance testing is recommended in many international guidelines.
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