Publications by authors named "C Shrestha"
Golgi abnormalities have been linked to aging and age-related diseases, yet the underlying causes and functional consequences remain poorly understood. This study identifies the interaction between age-associated zinc deficiency and Golgi stress as a critical factor in cellular aging. Senescent Golgi bodies from human fibroblasts show a fragmented Golgi structure, associated with a decreased interaction of the zinc-dependent Golgi-stacking protein complex Golgin45-GRASP55.
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- Atopic dermatitis (AD) is a chronic skin condition that causes itching and inflammation, often treated with corticosteroids like dexamethasone for temporary relief, but not as a cure.
- Researchers explored a new non-invasive treatment called quantum molecular resonance (QMR), which showed promise in reducing AD-like skin lesions in a mouse model, minimizing immune cell infiltration and epidermal thickening.
- Transcriptome analysis identified genes, specifically IL36G and SPRR2B, that's linked to inflammation and skin changes; QMR significantly decreased their expression, suggesting QMR could be a potential new therapy for AD.
Aflatoxins (AFs), secondary metabolites produced by fungi, pose significant health risks, especially to children and elderly individuals. In developing countries such as Nepal, the tropical climate promotes fungal growth, leading to elevated levels of AF in animal feed and milk. In this study, we aimed to investigate the occurrence of aflatoxin M1 (AFM1) in dairy milk from the Kathmandu District and to assess husbandry practices contributing to contamination.
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- - Cystic fibrosis (CF) is a persistent disease linked to the dysfunctional CFTR protein, which influences immune responses; however, the role of the epithelial sodium channel (ENaC) in CF is not fully understood.
- - Research found that ENaC is overexpressed in immune cells from CF patients, which contributes to impaired immune functions such as phagocytosis and inflammatory response.
- - Treatment with Amiloride, an ENaC inhibitor, improved the function of CF macrophages by normalizing oxidative stress production and reducing inflammation, suggesting that targeting ENaC could be beneficial for CF therapies.
Background: Most autistic individuals reside in low- and middle-income countries (LMIC) and have limited access to medical providers and specialists. Support for delivery of psychosocial interventions by non-specialists is growing to address this mental health care gap. This scoping review involved a systematic analysis of studies of non-specialist delivered psychosocial interventions for children and adolescents diagnosed with autism and living in low- and middle-income countries.
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