ACS Appl Mater Interfaces
July 2024
Transcriptional activation, based on Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9) and known as CRISPR activation (CRISPRa), is a specific and safe tool to upregulate endogenous genes. Therefore, CRISPRa is valuable not only for analysis of molecular mechanisms of cellular events, but also for treatment of various diseases. Regulating autophagy has been proposed to enhance effects of some therapies.
View Article and Find Full Text PDFAim: This study examines patterns and predictors of site-specific recurrence to explore the causes of local recurrence of cervical cancer.
Methods: Radical hysterectomy was performed in 121 patients (stage IB-IIB). Nerve-sparing was performed whenever possible.
Context: A conceptual framework for advance care planning is lacking in societies like Japan's valuing family-centered decision-making.
Objectives: A consensus definition of advance care planning with action guideline adapted to Japanese society.
Methods: We conducted a multidisciplinary modified Delphi study 2020-2022.