Publications by authors named "C Sheldrake"
Objective: To compare pharmacy students' intention to practise in a rural setting expressed in their first year of university with that expressed during their final year.
Design: Longitudinal survey of students in their first and final years.
Setting: Tertiary educational institution.
Objectives: The aim was to investigate the pharmacokinetics of intranasal sumatriptan (administered using a novel bi-directional powder delivery device) and study its effects on quantitative electroencephalography in patients with migraine. The safety profiles of the two formulations were also compared.
Methods: The pharmacokinetics of intranasal sumatriptan (10 mg and 20 mg) administered using a novel breath-actuated bi-directional powder delivery device were compared with subcutaneous sumatriptan (6 mg), along with an investigation of their effects on the electroencephalogram (EEG) following glyceryl trinitrate (GTN) challenge in 12 patients with migraine using a randomized, three-way cross-over design.
Evaluation of a pharmacist-led, medicines education program for Aboriginal Health Workers.
Rural Remote Health
February 2009
Introduction: The health of Indigenous Australians is exceptionally poor compared with that of non-Indigenous Australians. Cardiovascular diseases are the leading cause of death, the death rate being at least 2.7 times higher than the total Australian population.
View Article and Find Full Text PDFThe mutagenicity of emissions from eight binder systems used in steel foundries.
Am Ind Hyg Assoc J
September 1986
Article Synopsis
- The study assessed the mutagenic activity of emissions generated from pouring molten steel into sand molds made with eight different binder systems, using the Ames Salmonella assay for testing.
- The sampling apparatus involved air filtration through glass fiber filters and impingers filled with ice-cold methanol to capture airborne particles.
- Results indicated that all binder systems produced mutations, with the shell-core system showing the highest mutagenic activity, particularly when an S-9 extract was included, while other systems had varying levels of mutagenic effects.
Article Synopsis
- Workers in ferrous foundries face a heightened risk of lung cancer due to exposure to harmful emissions during the steel casting process.
- Emissions from pouring hot metal into sand molds contain various organic compounds, which have been found to have strong mutagenic effects in laboratory tests.
- Analysis of these emissions revealed that many identified compounds are alkyl derivatives of polycyclic aromatic hydrocarbons, including known carcinogens like benz[a]anthracene and benzo[a]pyrene.