Non-destructive, continuous monitoring of biochemical, mechanical, and structural maturation in engineered tissue.

Regulatory guidelines for tissue engineered products require stringent characterization during production and necessitate the development of novel, non-destructive methods to quantify key functional parameters for clinical translation. Traditional assessments of engineered tissues are destructive, expensive, and time consuming. Here, we introduce a non-destructive, inexpensive, and rapid sampling and analysis system that can continuously monitor the mechanical, biochemical, and structural properties of a single sample over extended periods of time.

Multimodal Label-Free Imaging for Detecting Maturation of Engineered Osteogenic Grafts.

There is a critical need to develop noninvasive, nondestructive methods for assessing the quality of engineered constructs prior to implantation. Currently, the composition and maturity of engineered tissues are assessed using destructive, costly, and time-consuming biochemical and mechanical analyses. The goal of this study was to use noninvasive, multimodal imaging to monitor osteogenic differentiation and matrix deposition by human mesenchymal stem/stromal cells (MSCs) during in vitro culture.

A Real-Time High Performance Computation Architecture for Multiple Moving Target Tracking Based on Wide-Area Motion Imagery via Cloud and Graphic Processing Units.

This paper presents the first attempt at combining Cloud with Graphic Processing Units (GPUs) in a complementary manner within the framework of a real-time high performance computation architecture for the application of detecting and tracking multiple moving targets based on Wide Area Motion Imagery (WAMI). More specifically, the GPU and Cloud Moving Target Tracking (GC-MTT) system applied a front-end web based server to perform the interaction with Hadoop and highly parallelized computation functions based on the Compute Unified Device Architecture (CUDA©). The introduced multiple moving target detection and tracking method can be extended to other applications such as pedestrian tracking, group tracking, and Patterns of Life (PoL) analysis.

Impact of Shoulder Abduction Loading on Brain-Machine Interface in Predicting Hand Opening and Closing in Individuals With Chronic Stroke.

Background: Many individuals with moderate and severe stroke are unable to use their paretic hand. Currently, the effect of conventional therapy on regaining meaningful hand function in this population is limited. Efforts have been made to use brain-machine interfaces (BMIs) to control hand function.

Characterization of an improved polyimide-etalon all-optical transducer for high-resolution ultrasound imaging.

All-optical transduction of ultrasound provides high-frequency (>20 MHz) operation in the absence of electrical noise and distortion that hinders small-scale piezoelectric probes. Although fabrication of an all-optical 2-D array suitable for in vivo imaging remains incomplete, a thin-film structure integrating a polyimide film with a Fabry-Perot (etalon) receiver has been shown to be a viable candidate. We present here incremental improvements in the performance of a polyimide-etalon transducer and demonstrate imaging with an array configuration alternative to our previous study.