Publications by authors named "C Serrand"
Article Synopsis
- A multicenter study evaluated the impact of a restrictive fluid strategy versus a standard fluid strategy in ICU patients with septic shock, aiming to minimize fluid intake to avoid complications from positive fluid balance.
- By analyzing 48 patients over 5 days, the restrictive group received significantly less fluid (89.7 ml/kg vs. 114.3 ml/kg), resulting in a smaller cumulative fluid balance.
- However, after 28 days, both groups showed similar mortality and survival without life support, indicating no clear benefits of the restrictive strategy despite differences in fluid management during the initial week.
The prognostic value of BRAF V600 mutation level on clinical outcomes in patients with BRAF V600-mutated metastatic melanoma treated with BRAF and MEK inhibitors remains uncertain. The association was retrospectively analysed between BRAF V600 mutation level (defined as the ratio of the quantification of the BRAF V600 allele to the percentage of tumoral cells in the sample analysed) and progression-free and overall survival (PFS and OS, respectively) and 3-month response rate in a cohort of 58 patients with metastatic melanoma who harboured BRAF V600E/K mutations and received dual targeted-therapy BRAF/MEK inhibitors. The BRAF mutation level cut-off determined by the area under the receiver operating characteristic curve after internal validation by bootstrap methods was 0.
View Article and Find Full Text PDFObjective: People with intellectual disabilities (ID) have difficulty in accessing oral or written health information presented in a conventional manner what compromises prevention. This study aims to develop accessible information on breast, cervical and colorectal cancer screening for people with ID.
Method: The instructional material has been developed collaboratively by a team involving representatives from different scientific disciplines (medical and psychoeducational) and people with ID.
Article Synopsis
- The study aimed to evaluate how well an AI system can detect bone fractures compared to radiologists, using CT scans as the ultimate benchmark.
- It involved 94 adult patients and found that the AI had a sensitivity of 82% and specificity of 69%, meaning it missed some fractures and misidentified some normal cases.
- The radiologists performed better overall, with a sensitivity of 92% and specificity of 88%, indicating they were more accurate in diagnosing the fractures.
Background: Image-guided percutaneous lung biopsy (PLB) may lead to major complications requiring hospitalization. This study aims to evaluate the rate of major PLB complications and determine a predictive computed tomography (CT) score to define patients requiring hospitalization due to these complications.
Methods: This single-center retrospective study included all PLBs performed from July 2019 to December 2020 in Nimes University Hospital, France.