Publications by authors named "C Senore"
Background & Aims: A significant number of post fecal immunochemical test (FIT) colonoscopies in European-organized colorectal cancer (CRC) screening programs are performed beyond the recommended 31-day threshold due to overburdened colonoscopy services. We aimed to develop a simple predictive model to stratify CRC risk of FIT+ patients.
Methods: In a cohort of screenees undergoing colonoscopy following a positive (≥20 μg hemoglobin/g feces) OC-sensor FIT result between 2004 and 2019, we derived and validated logistic regression-based models including variables independently associated with CRC and advanced neoplasms.
Randomized Controlled Trials (RCT) demonstrated that guaiac-based fecal occult blood test (gFOBT), sigmoidoscopy, or colonoscopy are effective at reducing colorectal cancer (CRC) risk and mortality. Even if the impact of fecal immunochemical test (FIT) has not been evaluated within population-based RCT with mortality as the outcome, the results of comparative analyses with gFOBT provide strong indirect evidence of its effectiveness. Extensive information is also available on sensitivity and specificity of FIT, compared with gFOBT.
View Article and Find Full Text PDFBackground: The fecal immunochemical test for hemoglobin (FIT) is now a widely used non-invasive test in population-based organized screening programs for colorectal neoplasia. The positivity thresholds of tests currently in use are based on the fecal hemoglobin concentration (f-Hb), but the rationale for the adopted thresholds are not well documented. To understand current global usage of FIT in screening programs we conducted an international survey of the brands of FIT used, the f-Hb positivity threshold applied and the rationale for the choice.
View Article and Find Full Text PDFArticle Synopsis
- A guideline panel in Italy created recommendations for breast cancer screening to align with European Breast Cancer Guidelines, following the ADOLOPMENT approach for adaptation.
- The panel utilized the GRADE EtD framework, incorporating findings from a PubMed search specific to Italy, and included nine articles as contextual evidence.
- Thirteen finalized recommendations emphasize organized screening every 2 years for women aged 50-69, conditional screening for those aged 70-74, and advise against annual mammography for women 50 and older to enhance standardized processes and promote health equity.
Article Synopsis
- A significant portion of the disease burden in Italy is linked to lifestyle choices, specifically smoking and physical inactivity, prompting the need for a model to assess preventive interventions.
- The researchers developed a Markovian model to simulate health status and risk factors in the Italian population, providing insights on disease incidence and the effects of interventions over time.
- The model was validated with historical data and used to explore a hypothetical scenario of eradicating smoking and sedentary behavior, revealing potential long-term health benefits while highlighting the need for future model enhancements to integrate more data.