Preparation, Isolation, and Structural Characterization of Lewis Base Iminium Salts of 1,8-Diazabicyclo[5.4.0]undec-7-ene and Their Application as Green Reagents in an Aqueous Medium.

We report a state-of-the-art synthesis and isolation procedure for 13 Lewis base iminium salts (LBI) of 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), confirming their structures meticulously by different spectral data.

Organo NHC catalyzed aqueous synthesis of 4β-isoxazole-podophyllotoxins: anticancer, caspase activation, tubulin polymerization inhibition and molecular docking studies.

We present, for the first time, the organo--heterocyclic carbene (NHC) catalyzed 1,3-dipolar cycloaddition of 4β--propargyl podophyllotoxin (1) with aromatic nitrile oxides to afford regioselective 4β-isoxazolepodophyllotoxin hybrids (6a-n) in benign aqueous-organic media. Preliminary anticancer activity results showed that compound 6e displayed superior activity against MCF-7, HeLa and MIA PaCa2 human cell lines compared with podophyllotoxin. Compounds 6j and 6n showed greater activity against the MCF-7 cell line than the positive control.

The role of WO and dopants (ZrO and SiO) on CeO-based nanostructure catalysts in the selective oxidation of benzyl alcohol to benzaldehyde under ambient conditions.

Herein, the efficacy of WO-promoted CeO-SiO and CeO-ZrO mixed oxide catalysts in the solvent-free selective oxidation of benzyl alcohol to benzaldehyde using molecular oxygen as an oxidant is reported. We evaluated the effects of the oxidant and catalyst concentration, reaction duration, and temperature on the reaction with an aim to optimize the reaction conditions. The as-prepared CeO, CeO-ZrO, CeO-SiO, WO/CeO, WO/CeO-ZrO, and WO/CeO-SiO catalysts were characterized by X-ray diffraction (XRD), N adsorption-desorption, Raman spectroscopy, temperature-programmed desorption of ammonia (TPD-NH), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM).

Highly Efficient and Practical N-Heterocyclic Carbene Organocatalyzed Chemoselective N/C-Functionalization of Isatins with Green Chemistry Principles.

Ecofriendly N-heterocyclic carbene (NHC) organocatalysis can control the N-functionalization (aza-Michael addition) and C-functionalization (Morita-Baylis-Hillman reaction, MBH) of isatins in the absence of (1) a protecting group, (2) a stoichiometric reagent, and (3) heat energy. The challengeable N-functionalization of N-unsubstituted isatins into N-substituted (NS) isatins was realized through 10 mol % NHC and 10 mol % 1,8-diazabicyclo[5.4.

Ozone-driven photocatalyzed degradation and mineralization of pesticide, Triclopyr by Au/TiO2.

Triclopyr is a widely used pesticide which is non-biodegradable and enters aquatic systems. The ozone facilitated photocatalyzed degradation and mineralization of Triclopyr using Au-loaded titania as heterogeneous catalyst is reported. The oxidative degradation activity of the hazardous pesticide was investigated at pH 7.