Publications by authors named "C Scully"
Background: Periparturient reproductive complications appear to be common in hospitalized goats. More information is needed about periparturient reproductive complications and survival in goats with these conditions.
Objective: Identify exposure factors associated with nonsurvival in periparturient does hospitalized ≤1 day or ≥2 days.
Objective: To evaluate the sedation quality of an IM injection of a commercially available medetomidine-vatinoxan combination (ZEN) in healthy goats and sheep and discern species differences in cardiopulmonary parameters.
Methods: 10 apparently healthy adult university-owned research Black Bengal-crossbreed goats and 10 adult Gulf Coast native and Katahdin sheep were enrolled in this prospective experimental study from June 27 to July 27, 2023. All animals were sedated on 1 occasion with 0.
A GENERATIVE APPROACH TO TESTING THE PERFORMANCE OF PHYSIOLOGICAL CONTROL ALGORITHMS.
ASME Lett Dyn Syst Control
August 2024
Article Synopsis
- Physiological closed-loop control algorithms are essential for creating personalized healthcare systems that cater to individual patient needs, which can benefit from computational evaluations accounting for patient variability.
- This paper introduces a generative approach that uses a physiological model to simulate virtual subjects, enabling the testing of these algorithms against diverse physiological behaviors to assess performance metrics across a representative population.
- The findings demonstrate this generative testing method's effectiveness in evaluating a closed-loop fluid resuscitation control algorithm, offering a promising solution for efficient pre-clinical testing of healthcare technologies.
Physiological closed-loop controlled (PCLC) medical devices, such as those designed for blood pressure regulation, can be tested for safety and efficacy in real-world clinical settings. However, relying solely on limited animal and clinical studies may not capture the diverse range of physiological conditions. Credible mathematical models can complement these studies by allowing the testing of the device against simulated patient scenarios.
View Article and Find Full Text PDFPulse oximetry represents a ubiquitous clinical application of optics in modern medicine. Recent studies have raised concerns regarding the potential impact of confounders, such as variable skin pigmentation and perfusion, on blood oxygen saturation measurement accuracy in pulse oximeters. Tissue-mimicking phantom testing offers a low-cost, well-controlled solution for characterizing device performance and studying potential error sources, which may thus reduce the need for costly in vivo trials.
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