Teeth Baring as a Model to Understand Complex Facial Signals in a Tolerant Macaque Species.

Facial communication regulates many aspects of social life in human and nonhuman primates. Empirically identifying distinct facial expressions and their underlying functions can help illuminate the evolution of species' communicative complexity. We focused on bared-teeth faces (BTFs), a highly versatile facial expression in the tolerant macaque Macaca tonkeana.

Unveiling directional physiological coupling in human-horse interactions.

This research investigates the human-horse bond, aiming to unveil the physiological mechanisms regulating interspecies interactions. We hypothesized observing a physiological synchronization in human-horse dynamics, akin to human interactions. Through time-frequency Granger causality analysis of heart rate variability (HRV) and behavioral data, this study reveals the establishment of bidirectional synchronization in HRV between humans and horses.

JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer's disease.

Adult neurogenic decline, inflammation, and neurodegeneration are phenotypic hallmarks of Alzheimer's disease (AD). Mobilization of transposable elements (TEs) in heterochromatic regions was recently reported in AD, but the underlying mechanisms are still underappreciated. Combining functional genomics with the differentiation of familial and sporadic AD patient derived-iPSCs into hippocampal progenitors, CA3 neurons, and cerebral organoids, we found that the upregulation of the AP-1 subunit, c-Jun, triggers decondensation of genomic regions containing TEs.