Publications by authors named "C Schulte"
Background: It is well known that myelin disruption and neuroinflammation are early and distinct pathological hallmarks in multiple system atrophy (MSA) as well as in idiopathic Parkinson's disease and in other atypical Parkinsonian syndromes. The objective of this study was to assess the value of non-neuronal biomarker candidates that reflect myelin disruption and neuroinflammation.
Methods: Myelin basic protein (MBP) and the soluble form of TREM2 were quantified in a comprehensive movement disorder cohort from two different neurological centers, comprising a total of 171 CSF samples.
Background: Atrial fibrillation is associated with cognitive dysfunction. Atrial cardiomyopathy has been correlated with both entities. We aimed to characterize the association of echocardiographic parameters of atrial cardiomyopathy with cognitive function and cerebral changes.
View Article and Find Full Text PDFThe contribution of deubiquitylating enzymes (DUBs) to β-Catenin stabilization in intestinal stem cells and colorectal cancer (CRC) is poorly understood. Here, and by using an unbiassed screen, we discovered that the DUB USP10 stabilizes β-Catenin specifically in APC-truncated CRC in vitro and in vivo. Mechanistic studies, including in vitro binding together with computational modelling, revealed that USP10 binding to β-Catenin is mediated via the unstructured N-terminus of USP10 and is outcompeted by intact APC, favouring β-catenin degradation.
View Article and Find Full Text PDFArticle Synopsis
- - Post-viral symptoms have gained attention during the COVID-19 pandemic, with increased reports after SARS-CoV-2 infection compared to other viruses like influenza.
- - A study analyzing data from 573,791 individuals found that COVID-19 patients experienced post-viral symptoms and tissue damage more frequently than those with influenza or other controls, though symptom persistence was similar for both infections.
- - The findings highlight the significant burden of post-viral symptoms from COVID-19, emphasizing the need for further research into effective treatments as the disease remains a serious health concern.
Regional differences, repeated use, and costs of emergency medical services in Germany.
Med Klin Intensivmed Notfmed
September 2024
Background: Little is known about regional differences regarding the utilization and costs of emergency medical services (EMS) in Germany. Evidence on characteristics of repeated use of EMS is also scarce.
Objectives: To compare German federal states regarding the utilization and costs of EMS and to analyze characteristics of repeated EMS use.