Publications by authors named "C Scazzone"
The aim of this systematic review was to evaluate the diagnostic accuracy of molecular-based LTPs serum sIgE for the diagnosis of food allergies in patients with suspected allergy to one of the LTPs-containing foods. Cohort, prospective or retrospective cross-sectional studies were considered for inclusion in this review. Oral food challenge (both open and double-blind placebo-controlled) was the reference standard for the diagnosis.
View Article and Find Full Text PDFArticle Synopsis
- - The study investigates the significance of antinuclear antibodies (ANA) patterns in patients with liver diseases, focusing on autoimmune liver disease (AILD).
- - Out of 396 patients tested, 33% were diagnosed with AILD, predominantly autoimmune hepatitis (AIH); specific ANA patterns showed varied prevalence among different liver diseases.
- - The results indicate that certain ANA patterns (like AC1 for AIH and AC21 for primary biliary cholangitis) correlate strongly with specific liver conditions, suggesting their potential importance in clinical diagnosis.
Background: Enzyme-linked immunosorbent assay (ELISA) is the most-used method for neurofilament light chain (NfL) quantification in cerebrospinal fluid (CSF). Recently, fully automated immunoassays for NfL measurement in CSF and blood have allowed high reproducibility among laboratories, making NfLs suitable for routine use in clinical practice. In this study, we compared the Uman Diagnostics NF-light ELISA with the fully automated platform Lumipulse.
View Article and Find Full Text PDFBackground And Aims: This study aims to assess the association between APOE genotype and biomarkers of neurodegeneration in Alzheimer's disease (AD).
Methods: We performed a retrospective observational study at the University Hospital "P. Giaccone" in Palermo, Italy.
Cerebrospinal fluid (CSF) core biomarkers of Alzheimer's disease (AD), including amyloid peptide beta-42 (Aβ42), Aβ42/40 ratio, and phosphorylated tau (pTau), are precious tools for supporting AD diagnosis. However, their use in clinical practice is limited due to the invasiveness of CSF collection. Thus, there is intensive research to find alternative, noninvasive, and widely accessible biological matrices to measure AD core biomarkers.
View Article and Find Full Text PDF