Publications by authors named "C Scarcella"
Article Synopsis
- * The study included 177 patients, showing that elevated FC levels were linked to poorer clinical responses and worse long-term outcomes, including complications and mortality.
- * Results indicated that high FC levels are more common in complicated cases of CD and NCEs, suggesting that FC could be a useful marker for assessing disease severity and predicting future health issues.
Objective: To estimate prevalence and incidence of thrombotic Primary Antiphospholipid Syndrome (PAPS) in the general population aged 18-49 years.
Methods: The study was carried out in Valtrompia, a valley in northern Italy, in 2011-2015. The identification of PAPS cases leveraged three integrated sources: 1) Rheumatology Unit at the University Hospital; 2) General Practitioners; 3) hospital discharge codes of patients admitted for thrombotic events.
Background: Few data are available on flow cytometry (FC) for monitoring intraepithelial lymphocytes (IELs) in refractory celiac disease (RCD), non-responsive celiac disease (NRCD), and non-celiac enteropathies (NCEs).
Aims: 1) To investigate the significance of monitoring IELs immunophenotype with FC in patients with NRCD, RCD and NCEs; 2) to evaluate FC concordance with immunohistochemistry (IHC) and γ-TCR clonality analysis.
Methods: Patients investigated between January-2012 and February-2023 were divided into two groups: 1)confirmed RCD or NRCD being investigated for persistent symptoms and suspected complications of celiac disease (CD); 2)NCEs lacking clinical/histological response.
Article Synopsis
- Whipple's disease (WD) is a rare but serious infection caused by Tropheryma whipplei, often misdiagnosed due to its symptom similarity with rheumatological diseases, leading to potential mismanagement.
- The study tracked 45 WD patients over 21 years and found that lower erythrocyte sedimentation rate (ESR) and platelet (PLT) counts at diagnosis were significant predictors for the development of immune reconstitution inflammatory syndrome (IRIS).
- Despite identifying these clinical indicators, the prevalence of IRIS remained constant at 22.2% over the two-decade observation period.