Publications by authors named "C Sato"
Sulforaphane (SFN), an isothiocyanate found in plants of the Brassicaceae family, possesses antioxidant, apoptosis-inducing, and radiosensitizing effects. As one of the mechanisms of cytotoxicity by SFN, SFN has been suggested to be involved in the induction of DNA damage and inhibition of DNA repair. Recently, we reported on the potency of SFN in inducing single-ended double-strand breaks (DSBs) that are caused by the collision of replication forks with single-strand breaks (SSBs).
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- The study analyzed glycan biomarkers in serum to understand their relationship with chronic inflammatory demyelinating polyneuropathy (CIDP) and treatment effects.
- Significant differences were found in N-glycan levels, particularly lower sialylated N-glycans in CIDP patients compared to healthy controls, while O-glycan levels remained unchanged.
- Lower sialylated N-glycan levels may indicate therapeutic resistance and could serve as a potential biomarker for CIDP’s pathophysiology.
Introduction: The pathophysiology of burn wound conversion is not fully understood. Animal models are needed to elucidate the underlying mechanisms and develop treatments. Here, we established a new reproducible mouse model that simulates this process, thereby facilitating studies of burn wound conversion.
View Article and Find Full Text PDFVisceral disseminated varicella zoster virus (VZV) infection is a severe complication, characterized by a notably high mortality rate. Herein, we present a case of a 36-year-old-man involving visceral disseminated VZV infection that emerged during remission induction therapy involving high-dose prednisolone (PSL), mycophenolate mofetil (MMF), and hydroxychloroquine for lupus nephritis. Two months after starting the immunosuppressive therapy, he experienced a rapid onset of severe upper abdominal pain.
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- Effective blood sampling times for vancomycin AUC estimation have not been clearly defined, prompting this study to explore different sampling times during dosing intervals.
- Six participants were studied after receiving intravenous vancomycin, with AUC estimated using various software and models, assessing accuracy through bias and imprecision.
- The study identified optimal blood sampling times of 2.5 and 5.5 hours post-injection for certain software, suggesting improved therapeutic drug monitoring could result from standardized sampling times.