Novel In-Office KTP Laser Treatment of Anterior Glottic Webs.

Objective: Acquired anterior glottic webs are the result of trauma, iatrogenic, radiation, or inflammation to the anterior commissure, resulting in narrowing of the airway and elevated pitch. They are very challenging to treat, and contemporary management strategies typically involve repeat procedures under general anesthesia with high rates of web recurrence. We aim to describe a novel treatment for anterior glottic webs with potassium titanyl phosphate (KTP) laser treatment that are performed in-office under topical anesthesia.

Posterior Cricoarytenoid Muscle Chemodenervation Can Improve Voice in Recalcitrant Dysphonia in Unilateral Vocal Fold Paresis With Synkinesis.

Objectives: Patients with unilateral vocal fold paresis and unfavorable posterior cricoarytenoid (PCA) muscle synkinesis can be challenging to treat with medialization procedures alone. Arytenoid repositioning procedures are generally considered contraindicated in mobile vocal folds. We present two cases of persistent dysphonia following type I thyroplasty for vocal fold paresis that improved after botulinum toxin-A (BTX-A) injection into the PCA muscle.

Spatial Architecture of Single-Cell and Vasculature in Tumor Microenvironment Predicts Clinical Outcomes in Triple-Negative Breast Cancer.

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited treatment options, which warrants the identification of novel therapeutic targets. Deciphering nuances in the tumor microenvironment (TME) may unveil insightful links between antitumor immunity and clinical outcomes; however, such connections remain underexplored. Here, we employed a data set derived from imaging mass cytometry of 71 TNBC patient specimens at single-cell resolution and performed in-depth quantifications with a suite of multiscale computational algorithms.