Publications by authors named "C Sande"
Increased immune evasion by emerging and highly mutated SARS-CoV-2 variants is a key challenge to the control of COVID-19. The majority of these mutations mainly target the spike protein, allowing the new variants to escape the immunity previously raised by vaccination and/or infection by earlier variants of SARS-CoV-2. In this study, we investigated the neutralizing capacity of antibodies against emerging variants of interest circulating between May 2023 and October 2024 using sera from representative samples of the Kenyan population.
View Article and Find Full Text PDFAngiomyofibroblastoma is a benign, usually small neoplasm typically constituted by spindle-shaped and epithelioid cells in a vascularized, myxoid-fibrous stromal background. It is most often seen in the superficial genitalia of female patients of reproductive age. However, various clinical and histologic features have been reported, including tumors in male patients, malignant transformation, extragenital sites, huge sizes, and a prominent lipomatous pattern.
View Article and Find Full Text PDFControlled human infection models (CHIMs) are a critical tool for the understanding of infectious disease progression, characterising immune responses to infection and rapid assessment of vaccines or drug treatments. There is increasing interest in using CHIMs for vaccine development and an obvious need for widely available and fit-for-purpose challenge agents. Inno4Vac is a large European consortium working towards accelerating and de-risking the development of new vaccines, including development of CHIMs for influenza, respiratory syncytial virus and Clostridium difficile.
View Article and Find Full Text PDFArticle Synopsis
- RSV is a significant cause of infant mortality and poses health risks for older adults, prompting the development of various vaccines and treatments, including a protein-based maternal vaccine and monoclonal antibodies (mAb) specifically for infants.* -
- High-income countries have seen public health benefits from using nirsevimab, and several vaccines for older adults have also been approved, with ongoing clinical trials for multiple vaccine types targeting different age groups.* -
- There's a need to address disparities in vaccine access, especially in low- and middle-income countries, with plans to advance RSV vaccination efforts globally in the near future.*
Next Steps: Studying Diabetic Foot Infections with Next-Generation Molecular Assays.
Curr Infect Dis Rep
December 2023
Article Synopsis
- In 2019, concerns were raised by the International Working Group on the Diabetic Foot about using molecular microbiology techniques for diagnosing infections in diabetic foot ulcers, which this review aims to address.
- Recent studies have demonstrated that metagenomic and metatranscriptomic approaches can be applied to diabetic foot ulcer samples, but they featured small sample sizes and potential biases, indicating a need for larger longitudinal research.
- Currently, high-throughput molecular microbiology techniques are not suitable for clinical use as routine diagnostics, but advancements in these technologies could enhance patient care in the future.