Publications by authors named "C Sandberg"
The brain's primary immune cells, microglia, are a leading causal cell type in Alzheimer's disease (AD). Yet, the mechanisms by which microglia can drive neurodegeneration remain unresolved. Here, we discover that a conserved stress signaling pathway, the integrated stress response (ISR), characterizes a microglia subset with neurodegenerative outcomes.
View Article and Find Full Text PDFArticle Synopsis
- More adults with congenital heart disease are getting long-term complications like ischemic stroke, which is when blood flow to the brain is blocked.
- A study in Sweden looked at nearly 9,000 patients and found that about 1.5% had a stroke after 10 years.
- Factors like age, diabetes, and specific heart problems made strokes more likely, and about half of those who had a stroke were already on medication to prevent it.
Article Synopsis
- Tulving defined semantic memory as a large storehouse of meanings crucial for language and cognition, prompting various fields to research it with unique methods and terms.
- The varied interpretations of key concepts like "concept" across disciplines create confusion, contributing to the replication crisis in psychology and impacting communication and theory development.
- To address these issues, a multidisciplinary semantic glossary is being developed to provide clear definitions and foster shared understanding among researchers while acknowledging the challenges of bias and prescriptiveness.
Background: An association between impaired exercise capacity and risk of mortality has been reported among adults with congenital heart disease (CHD). Over the years, treatment methods have improved and may influence outcome. Hence, we report data from a national cohort reflecting a contemporary population.
View Article and Find Full Text PDFArticle Synopsis
- * It involved 814 patients aged 40 and above from various countries, finding that 52.3% were robust, 41.9% were prefrail, and 5.8% were frail, with 38.8% showing cognitive dysfunction.
- * The research indicates that factors like older age, female sex, and comorbidities are linked to frailty and cognitive issues, suggesting that these challenges are significant even in patients with mild heart defects, thus advocating for regular assessments.*