In Silico Hydrolysis of Lupin ( L.) Conglutins with Plant Proteases Releases Antihypertensive and Antidiabetic Peptides That Are Bioavailable, Non-Toxic, and Gastrointestinal Digestion Stable.

Lupin ( L.) proteins are potential sources of bioactive peptides (LBPs) that can inhibit dipeptidyl peptidase IV (DPP-IV) and angiotensin I-converting enzyme (ACE-I) activity. However, the capacity of different enzymes to release LBPs, the pharmacokinetic and bioactivities of the peptides released, and their binding affinities with the active sites of DPP-IV and ECA-I are topics scarcely addressed.

Nail Disorders in Patients Living with HIV Coinfected with Monkeypox: A Clinical Study in 69 Mexican Cases.

Introduction: Several infectious diseases can present nail manifestations, which may be useful for diagnosis and prognosis, and only a few reports have been made regarding monkeypox (mpox). The objective of this study was to describe the clinical characteristics of nail alterations in patients living with HIV coinfected with mpox.

Methods: A prospective, cross-sectional study included patients living with HIV/AIDS, coinfected with mpox.

Reorganization of the flagellum scaffolding induces a sperm standstill during fertilization.

Mammalian sperm delve into the female reproductive tract to fertilize the female gamete. The available information about how sperm regulate their motility during the final journey to the fertilization site is extremely limited. In this work, we investigated the structural and functional changes in the sperm flagellum after acrosomal exocytosis (AE) and during the interaction with the eggs.

Intracellular Mg concentrations are differentially regulated in the sperm head and mid-piece in acrosome reaction inducing conditions.

The sperm ability to fertilize involves the regulation of ATP levels. Because inside cells, ATP is complexed with Mg ions, changes in ATP levels result in changes in intracellular Mg concentration ([Mg]), which can be followed using intracellular Mg sensors such as Mag-520. In this work, we tested conditions known to decrease sperm ATP such as starvation and capacitation.