Publications by authors named "C Samuels"
At the maternal-fetal interface, tightly regulated levels of retinoic acid (RA), the physiologically active metabolite of vitamin A, are required for embryo implantation and pregnancy success. Herein, we utilize mouse models, primary human cells, and pharmacological tools to demonstrate how depletion of RA signaling via RA receptor (RAR) disrupts implantation and progression of early pregnancy. To inhibit RAR signaling during early pregnancy, BMS493, an inverse pan-RAR agonist that prevents RA-induced differentiation, was administered to pregnant mice during the peri-implantation period.
View Article and Find Full Text PDFSince 1968, the United States Transuranium and Uranium Registries (USTUR) has studied the biokinetics and tissue dosimetry of uranium and transuranium elements in nuclear workers. As part of the USTUR collaboration with the Million Person Study (MPS) of Low-Dose Health Effects, radiation dose to different parts of the human heart is being estimated for workers with documented intakes of 239Pu or 226Ra. The study may be expanded for workers with intakes of 238U and other radionuclides.
View Article and Find Full Text PDFThe American radium dial worker (RDW) cohort of over 3,200 persons is being revisited as part of the Million Person Study (MPS) to include a modern approach to RDW dosimetry. An exceptional source of data and contextualization in this project is an extensive collection of electronic records (requiring 43 gigabytes (GB) of storage) digitized from existing microfilm and microfiche housed at the United States Transuranium and Uranium Registries (USTUR). Although the type, extent, and quality (e.
View Article and Find Full Text PDFArticle Synopsis
- The Million Person Study (MPS) investigates the health impacts of gradual exposure to ionizing radiation on over one million U.S. radiation workers and veterans, focusing on both cancer and non-cancer conditions.
- Recent efforts have highlighted mortality patterns related to neurological and behavioral disorders, such as Parkinson's and Alzheimer's diseases, by analyzing claims data from Medicare beneficiaries.
- To manage the extensive and complex dataset, the MPS is developing specialized open-source software (Colossus) to facilitate detailed evaluation of health outcomes and related factors from the collected health information.
Article Synopsis
- This study explores how circadian preference (morning vs. evening tendencies) and sleep inertia (feeling sluggish after waking) affect marathon performance, especially since marathons typically happen in the early morning.
- Researchers recruited 936 participants from a 2016 city marathon and found that runners with a preference for the evening and higher sleep inertia tended to have slower completion times.
- The findings suggest that understanding these factors could help tailor training programs for specific runners, potentially improving their performance during races.