Publications by authors named "C Salazar-Lopez"
Purpose: To compare the DNA damage in granulosa cells (GCs) of women undergoing ovarian-stimulated cycles with four widely used recombinant human follicle-stimulating hormones (rhFSH) in in vitro fertilization (IVF) protocols (Corneumon, Gonal-F, Pergoveris and Puregon).
Methods: A randomized trial was carried out at a Mexican hospital. GCs were isolated from 18 women with infertility undergoing assisted reproductive techniques (ART).
Article Synopsis
- PFDA is a synthetic compound shown to harm somatic cells, but its effects on germ cells, specifically porcine oocytes, were previously unstudied.
- The study found that PFDA significantly reduces oocyte viability and maturation, with a lethal concentration of 7.8 μM and an inhibition of maturation at 3.8 μM.
- PFDA also increases intracellular calcium levels and disrupts communication between cumulus cells and oocytes, suggesting that these changes contribute to the negative effects on oocyte health and development, raising concerns about its use in consumer products.