A comparative study of clinical effectiveness of fissure sealing with and without bonding systems: 3-year results.

Aim: This prospective clinical study evaluated the sealant retention rate and caries-preventive efficacy of two fissure sealing techniques over a 3-year period.

Methods: Subjects (87) aged between 6.5 and 11.

Effect of choline supplementation on fatigue in trained cyclists.

The availability of choline, the precurser of the neurotransmitter, acetylcholine, in the diet is sufficient to provide the body's requirements under normal conditions. However, preliminary evidence indicates that depletion of choline may limit performance, while oral supplementation may delay fatigue during prolonged efforts. A double-blind cross-over design was used to determine the relationship between plasma choline and fatigue during supramaximal brief and submaximal prolonged activities.