Publications by authors named "C Sackesen"
The milk ladder (ML) approach, which is the gradual reintroduction of the milk allergen from the least allergenic forms to the most allergenic forms into the diet of the patients, has been utilized mostly in non-IgE-mediated but in some countries also in IgE-mediated-CMPA due to its possible benefits which include nutrition, quality of life and tolerance induction. Despite increasing interest, so far, there is no guideline on ML; thus, the use of this approach shows discrepancies among healthcare professionals as many factors such as dietary habits, patient history, test results, workload, and facilities of the hospitals, the anxiety of the parents/patients may affect the decision on how, when, where and whom to use ML. Here, we reviewed current data on implementing the ML, suggested a 4-step ML including receipts and amounts, and shared our experience on optimal patient selection, appropriate time and steps for initiating ML, and time intervals between the steps targeting the lowest risk of reaction.
View Article and Find Full Text PDFBackground: Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by epidermal skin barrier dysfunction and altered immune response. Electrical impedance spectroscopy (EIS) has been used as a novel tool to detect skin barrier changes in AD. EIS is a non-invasive measure of the electrical impedance of tissue and is sensitive to cellular structure and extracellular environment.
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- Hymenoptera venom allergy (HVA) is a major cause of severe allergic reactions; a study analyzed 76 adults and 36 children to explore clinical features and immunologic changes after venom immunotherapy (VIT).
- Cardiovascular symptoms were more common in adults, while children primarily experienced skin reactions; risk factors for severe reactions included lower urticaria rates and higher serum tryptase levels in adults.
- VIT significantly increased specific immunoglobulin G4 (sIgG4) levels in patients, with notable increases seen in Apis and Vespula groups, showing different allergic responses between adults and children after one year of treatment.
Background: Milk oral immunotherapy is the riskiest and most unpredictable form of oral immunotherapy. We aimed to produce a low allergenic product than conventional once baked-cake/muffin, to develop indirect in-house ELISA to check the tolerance status with milk products and evaluate IgE reactivity of patients' sera via western blotting (WB) and indirect in-house ELISA.
Method: A low allergenic product named biscotti-twice baked-cake was developed, and the total protein concentration was determined.
Article Synopsis
- * The research involved comparing height, weight, and nutrition-related blood markers in children with CMA or multiple food allergies to healthy controls, using a detailed food intake log for analysis.
- * Findings indicated that children with CMA and multiple food allergies had lower growth measures and nutritional intake, along with low blood calcium and high parathyroid hormone levels, pointing to potential bone health issues.