Publications by authors named "C SULTAN"
Neurosyphilis-induced dementia represents a severe manifestation of tertiary syphilis, characterized by cognitive and neuropsychiatric impairments. This condition arises from the progression of syphilis to the central nervous system, where the spirochete causes damage through invasion, chronic inflammation, and neurodegeneration. The pathophysiology involves chronic inflammatory responses, direct bacterial damage, and proteinopathies.
View Article and Find Full Text PDFPhospholipids are asymmetrically distributed in the plasma membrane (PM), and scramblases disrupt this asymmetry by shuffling phospholipids. We recently identified mouse Tmem63b as a membrane structure-responsive scramblase. Tmem63b belongs to the TMEM63/OSCA family of ion channels; however, the conservation of the scramblase activity within this family remains unclear.
View Article and Find Full Text PDFPhospholipids are asymmetrically distributed in the plasma membrane (PM), with phosphatidylcholine and sphingomyelin abundant in the outer leaflet. However, the mechanisms by which their distribution is regulated remain unclear. Here, we show that transmembrane protein 63B (TMEM63B) functions as a membrane structure-responsive lipid scramblase localized at the PM and lysosomes, activating bidirectional lipid translocation upon changes in membrane curvature and thickness.
View Article and Find Full Text PDFArticle Synopsis
- Endocrine-disrupting chemicals, like TCDD, may play a role in increasing female-specific cancers in Western countries, particularly affecting reproductive health.
- The study focused on how TCDD exposure alters the expression of small noncoding RNAs (sncRNAs) in KGN cells, examining both acute (3 hours) and chronic (72 hours) effects, and their implications for subsequent cell generations.
- Results showed that TCDD exposure led to a significant alteration in sncRNA expression, with a downregulation of sncRNAs associated with cell growth and proliferation, and an upregulation of those linked to cancer, suggesting the potential for TCDD to cause long-term cancer-promoting effects across generations.
Article Synopsis
- * Recent decades have seen a rise in the number of transgender people, with potential contributing factors including biological, genetic, environmental, and cultural influences, though the exact cause remains unclear.
- * A study on XY individuals exposed to the chemical diethylstilbestrol (DES) in utero found a notable prevalence of transgender identities among them, indicating that fetal exposure to xenoestrogens may impact male gender identity and behavior.