Predictive factors of incidental prostate cancer in patients undergoing surgery for presumed benign prostatic hyperplasia: an updated systematic review and meta-analysis.

Purpose: We aimed to identify the clinical predictors of incidental prostate cancer (IPCa) after surgery for presumed benign prostatic hyperplasia (BPH).

Methods: The literature was comprehensively searched using PubMed, Web of Science, Embase, and Cochrane databases in December 2024. We used pooled standardized mean difference (SMD) and odds ratio (OR) to describe the correlation between relevant risk factors and IPCa.

promoter hypomethylation correlates with enhanced immune cell infiltration, favorable prognosis, and immunotherapy response in melanoma.

Background: Immune checkpoint blockade (ICB)-based immunotherapy has significantly improved survival in advanced melanoma. However, many patients exhibit resistance to these therapies. This study examines the impact of promoter methylation on its expression, immune cell infiltration, and clinical outcomes, evaluating its potential as a prognostic and predictive biomarker for immunotherapy response.

Signal mining and analysis of ripretinib adverse events: a real-world pharmacovigilance analysis based on the FAERS database.

Background: Ripretinib is a tyrosine kinase inhibitor indicated for the treatment of adult patients with advanced gastrointestinal stromal tumors (GISTs) who have previously received treatment with at least three kinase inhibitors. The objective of this study was to evaluate adverse events(AEs) associated with ripretinib using data from the FDA Adverse Event Reporting System (FAERS) database.

Methods: Individual case safety reports (ICSRs) related to of ripretinib from 2020 Q2 to 2024 Q2 were extracted from the FAERS database.

The Effect of Thermal Processing on the Microstructure and Properties of a Novel Nickel-Based Powder Metallurgy Superalloy.

A novel nickel-based powder metallurgy superalloy was processed using two different thermal-mechanical processes, including hot isostatic pressed (As-HIP) and hipped + hot extruded + isothermally-forged (IF) heat treatments following two processed alloys, designated as As-HIP-HT and IF-HT. The objective of this study is to investigate the microstructure and mechanical property evolution in a nickel-based powder disk alloy fabricated by two processes. The findings revealed that both As-HIP and IF alloys underwent substantial recrystallization, with grains in the IF alloy being finer.

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3.

Hepatic stellate cells (HSCs) have a central pathogenetic role in the development of liver fibrosis. However, their fibrosis-independent and homeostatic functions remain poorly understood. Here we demonstrate that genetic depletion of HSCs changes WNT activity and zonation of hepatocytes, leading to marked alterations in liver regeneration, cytochrome P450 metabolism and injury.