Publications by authors named "C S Witt"
The Specialized Donor Care Facility Model Improves Operating Room Efficiency.
Ann Thorac Surg Short Rep
September 2024
Background: Organ procurement organizations coordinate organ donation through 2 distinct models of care: the conventional model, in which donors are managed at hospitals where brain death occurs, and the specialized donor care facility (SDCF) model, where brain dead donors are transferred to a freestanding facility. The aim of this study is to compare operating room efficiency for procurements between the SDCF and conventional models of care.
Methods: We performed a prospective analysis of operating room efficiency between thoracic donor procurement operations performed at a SDCF and other organ procurement organizations using the conventional model of care.
Background: Mobile health (mHealth) refers to using mobile communication devices such as smartphones to support health, health care, and public health. mHealth interventions have their own nature and characteristics that distinguish them from traditional health care interventions, including drug interventions. Thus, randomized controlled trials (RCTs) of mHealth interventions present specific methodological challenges.
View Article and Find Full Text PDFBackground: The Danish National Patient Registry (DNPR) is a valuable resource for population-based research, but the validity of routine registration of advanced heart failure (HF) treatments within the registry is unknown. We, therefore, investigated the validity of HF, advanced HF treatments, and HF readmissions in the DNPR.
Methods: We randomly sampled patients registered at a Danish University Hospital during 2017-2021 from the DNPR.
Article Synopsis
- Ventricular arrhythmias (VAs) are uncommon but can occur after electrical cardioversion (ECV) for atrial fibrillation (AF), with an incidence of about 0.2% based on a study of nearly 12,000 ECV procedures.
- The study involved 23 patients who experienced VAs within 10 days of ECV, with most cases developing 28.5 hours after the procedure, and a significant number had underlying health issues like congestive heart failure.
- The findings suggest that while VAs post-ECV are rare, they can be life-threatening, especially in patients with certain risk factors, indicating that careful monitoring is essential for these individuals.
Article Synopsis
- A better understanding of chronic lung allograft dysfunction (CLAD) is needed, as it leads to high mortality rates after lung transplants.
- The study focused on a genetic variation (C3R102G) that enhances complement activation, finding that lung transplant recipients with this variation tend to have poorer outcomes related to CLAD, especially if they develop donor-specific antibodies.
- In experiments with mice, decreased regulation of the complement system resulted in worse airway damage and increased B cell activity, linking genetic predisposition to complement activation with worse survival outcomes after lung transplantation.