Publications by authors named "C S Walpole"
Article Synopsis
- Scientists found a link between a gene called IRX4 and the risk of getting prostate cancer, but they don’t fully understand how it works yet.
- They discovered that when prostate cancer tumors have more IRX4, they also have gene signals that respond to male hormones, which might change how cancer cells behave.
- A specific genetic change (called INDEL) near the IRX4 gene has been linked to a higher risk of prostate cancer and affects how the gene works, making it a possible way to predict treatment success for patients.
Immunodeficient mice bearing human immune systems, or "humanized" chimeric mice, are widely used in basic research, along with the preclinical stages of drug development. Nonobese diabetic-severe combined immunodeficiency (NOD-SCID) IL2Rγ (NSG) mice expressing human stem cell factor, granulocyte-macrophage colony stimulating factor, and interleukin-3 (NSG-SGM3) support robust development of human myeloid cells and T cells but have reduced longevity due to the development of fatal hemophagocytic lymphohistiocytosis (HLH). Here, we describe an optimized protocol for development of human immune chimerism in NSG-SGM3 mice.
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- * Pks13 has been identified as a crucial target for developing new growth inhibitors for TB, with prior attempts using benzofuran inhibitors halted due to safety concerns.
- * Researchers have discovered a novel series of oxadiazole inhibitors that effectively target Pks13, showing better potency and safety profiles compared to previous compounds.
Characterisation of cell lines derived from prostate cancer patients with localised disease.
Prostate Cancer Prostatic Dis
September 2023
Article Synopsis
- Prostate cancer varies greatly in severity, ranging from slow-growing forms to aggressive types, but existing research cell lines mostly come from advanced cases, highlighting the need for new lines from early-stage localized disease.
- Researchers established four new cell lines from patients with localized prostate cancer, two from benign tissue and two from tumor tissue, using techniques like HPV16 immortalization and RNA sequencing to analyze their characteristics.
- The new cell lines retained an epithelial structure and showed a slower growth rate, differing significantly in gene expression from common metastatic prostate cancer cell lines, which may be important for further understanding of the disease's early stages.
Poor maternal diet during pregnancy is a risk factor for severe lower respiratory infections (sLRIs) in the offspring, but the underlying mechanisms remain elusive. Here, we demonstrate that in mice a maternal low-fiber diet (LFD) led to enhanced LRI severity in infants because of delayed plasmacytoid dendritic cell (pDC) recruitment and perturbation of regulatory T cell expansion in the lungs. LFD altered the composition of the maternal milk microbiome and assembling infant gut microbiome.
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