Phage therapy as a revolutionary medicine against Gram-positive bacterial infections.

Background: Antibiotic resistance among pathogenic bacteria has created a global emergency, prompting the hunt for an alternative cure. Bacteriophages were discovered over a century ago and have proven to be a successful replacement during antibiotic treatment failure. This review discusses on the scientific investigation of phage therapy for Gram-positive pathogens and general outlook of phage therapy clinical trials and commercialization.

Episode of coexisting infections with multiple dengue virus serotypes in central Karnataka, India.

Background: The co-circulation of multiple dengue virus serotypes has been reported in many parts of the world, including India; however, concurrent infection with more than one serotype of dengue virus in the same individual is rarely documented.

Method: An outbreak of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS) occurred in and around Davangere, Karnataka, from June 2011-March 2012. This is the first report from India with a high percentage of concurrent infections with different dengue virus serotypes circulating during one outbreak.

Carbon particles in airway macrophage as a surrogate marker in the early detection of lung diseases.

Background: It has been shown that inhalation of carbonaceous particulate matter may impair lung function in children.

Objective: Using the carbon content of airway macrophages as a marker of individual exposure to particulate matter derived from fossil fuel, we sought direct evidence for this association.

Methods: 300 children from puffed rice industrial areas and 300 children from population living in green zone were selected randomly.

Metallo Beta lactamase producing pseudomonas aeruginosa and its association with diabetic foot.

Pseudomonas aeruginosa strains that produce metallo beta lactamases (MBLs) are becoming increasingly prevalent in wound infections. The aim of the present study is to determine the clinical features, incidence, and to find out the antimicrobial susceptibility pattern of Pseudomonas aeruginosa in diabetic foot infections. Pus samples for bacterial culture were collected from 310 patients admitted with diabetic foot infections.