Publications by authors named "C S Stoddard"
Sweetpotato ( Lam.) is grown worldwide and is a staple food in many countries. One of the main constraints for sweetpotato production is cultivar decline, caused by the accumulation of viruses and subsequent losses of storage root yield and quality over years of vegetative propagation.
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- Prader-Willi syndrome (PWS) is a rare disorder marked by early muscle weakness, excessive eating, and obesity, often linked to deletions on chromosome 15.
- Some patients have smaller deletions that affect the SNORD116 gene cluster, which is believed to play a significant role in PWS symptoms, though its exact targets and functions remain unclear.
- Research using human embryonic stem cells revealed 42 genes that are consistently dysregulated in PWS, suggesting that SNORD116 may regulate a unique gene network that is disrupted in affected individuals.
Hajdu Cheney Syndrome (HCS), a monogenic disorder associated with NOTCH2 pathogenic variants, presents with neurological, craniofacial and skeletal abnormalities. Mouse models of the disease exhibit osteopenia. To determine the consequences of a HCS pathogenic variant in human cells, induced pluripotent NCRM1 and NCRM5 stem (iPS) cells harboring a NOTCH2 mutation or null for HES1 alleles were created.
View Article and Find Full Text PDFAngelman syndrome (AS) and Prader-Willi syndrome (PWS), two distinct neurodevelopmental disorders, result from loss of expression from imprinted genes in the chromosome 15q11-13 locus most commonly caused by a megabase-scale deletion on either the maternal or paternal allele, respectively. Each occurs at an approximate incidence of 1/15,000 to 1/30,000 live births and has a range of debilitating phenotypes. Patient-derived induced pluripotent stem cells (iPSCs) have been valuable tools to understand human-relevant gene regulation at this locus and have contributed to the development of therapeutic approaches for AS.
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- The SARS-CoV-2 virus has evolved to evade immune responses created by vaccines and previous infections, particularly through mutations in the spike protein's receptor binding domain.
- Researchers identified a group of S2 mAbs from convalescent individuals that target various regions in the spike protein, including one powerful mAb, C20.119, which effectively neutralizes multiple SARS-CoV-2 variants.
- Some mAbs displayed antibody-dependent cellular cytotoxicity (ADCC) and targeted regions of the spike protein that could lead to effective treatments, suggesting potential for developing new therapies for future pandemics.